{"id":143,"date":"2017-02-12T14:50:17","date_gmt":"2017-02-12T14:50:17","guid":{"rendered":"http:\/\/xn--nrdiagnosenerbrystkrft-o5b7b.dk\/?page_id=143"},"modified":"2017-02-12T14:50:24","modified_gmt":"2017-02-12T14:50:24","slug":"de-fantastiske-korsblomstrede-groensager","status":"publish","type":"page","link":"https:\/\/xn--nrdiagnosenerbrystkrft-o5b7b.dk\/index.php\/artikler\/de-fantastiske-korsblomstrede-groensager\/","title":{"rendered":"De fantastiske korsblomstrede gr\u00f8nsager"},"content":{"rendered":"

Broccoli, blomk\u00e5l og andre korsblomstrede gr\u00f8nsager indeholder helt unikke sundhedsfremmende plantestoffer, som har vist sig at hj\u00e6lpe med at forebygge starten p\u00e5 og standse progressionen af de fleste kr\u00e6ftformer, herunder brystkr\u00e6ft.[1]<\/a><\/p>\n

Broccoli kan standse cellecyklus f\u00f8r cellerne udvikler sig til kr\u00e6ft
\n<\/strong>N\u00e5r en celle deler sig, gennemg\u00e5r den en r\u00e6kke udviklingsstadier, f\u00f8r den har lavet en n\u00f8jagtig kopi af sig selv. Hvis DNA har f\u00e5et skader, kan cellecyklus forbig\u00e5ende blive standset ved nogle checkpoints, som tillader cellereparation. Defekt regulering af cellecyklus kan som bekendt resultere i flere mutationer, som bidrager til kr\u00e6ftudvikling, ligesom skaderne kan medf\u00f8re blokering af veje, som normalt ville f\u00f8re til selvdestruktion, hvis skaderne ikke kan repareres.[2]<\/a><\/p>\n

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Neutraliserer kr\u00e6ftfremkaldende stoffer
\n<\/strong>Indholdsstofferne i broccoli og andre korsblomstrede gr\u00f8nsager beskytter DNA mod oxidative skader som f\u00f8lge af giftstoffer med op til 28% reduktion i humane fors\u00f8g og kan p\u00e5 den m\u00e5de forebygge de indledende \u00e6ndringer, som kan f\u00f8re til kr\u00e6ft. Det sker bl.a. ved at aktivere de enzymer, som er i stand til at neutralisere de mange kr\u00e6ftfremkaldende stoffer, som vi uds\u00e6ttes for hver dag.[3]<\/a><\/p>\n

Nogle af disse findes i cigaretr\u00f8g, og et studie har vist, at kvindelige rygere, som tog 400 mg af indholdsstoffet I3C dagligt, reducerede deres niveauer af et st\u00e6rkt kr\u00e6ftfremkaldende stof i lungerne signifikant. Kemikalierne i cigaretter er faktisk ogs\u00e5 kendt for at have en negativ effekt p\u00e5 \u00f8strogenoms\u00e6tningen i kroppen.[4]<\/a><\/p>\n

Indholdsstoffet indole-3-carbinol (I3C) er et af de aktive indholdsstoffer i k\u00e5l, ikke mindst broccoli, som beskytter DNA ikke bare i brystv\u00e6vet, men ogs\u00e5 i andre v\u00e6v. Et dyrefors\u00f8g viste, at skadet DNA i brystcellerne blev reduceret med hele 91%.[5]<\/a> Lignende resultater s\u00e5s i leveren. Et andet studie, som blev publiceret i juli 2004 i det medicinske tidsskrift Carcinogenesis<\/em> viste, at I3C h\u00e6mmede kr\u00e6ftcellernes fortsatte deling, samtidig med, at flere af dem begik selvmord.<\/p>\n

Forskerne g\u00f8r opm\u00e6rksom p\u00e5, at 300 mg I3C dagligt som kapsel er den mindste dosis, hvis man vil beskytte sig mod brystkr\u00e6ft. Det opn\u00e5r du sikrest ved at tage tilskud, men suppl\u00e9r endelig flere gange om ugen med frisk broccoli, som indeholder alle de aktive indholdsstoffer.<\/p>\n

Referencer<\/strong>:
\n[1]<\/a> Weisburger JH. Antimutagens, anticarcinogens, and effective worldwide cancer prevention. J Environ Pathol Toxicol Oncol. 1999;18(2):85-93.
\nAggarwal BB, Ichikawa H. Molecular targets and anticancer potential of indole-3-carbinol and its derivatives. Cell Cycle. 2005 Sep;4(9):1201-15.
\nChang X, Tou JC, Hong C, et al. 3,3\u2019-Diindolylmethane inhibits angiogenesis and the growth of transplantable human breast carcinoma in athymic mice. Carcinogenesis. 2005 Apr;26(4):771-8.
\nRahman KW, Sarkar FH. Inhibition of nuclear translocation of nuclear factor-{kappa}B contributes to 3,3\u2019-diindolylmethane-induced apoptosis in breast cancer cells. Cancer Res. 2005 Jan 1;65(1):364-71.<\/p>\n

[2]<\/a> Stewart ZA, Westfall MD, Pietenpol JA. Cell-cycle dysregulation and anticancer therapy. Trends Pharmacol Sci. 2003;24(3):139-145.
\nJackson SJ, Singletary KW. Sulforaphane: a naturally occurring mammary carcinoma mitotic inhibitor, which disrupts tubulin polymerization. Carcinogenesis. <\/em>2004 Feb;25(2):219-27.<\/p>\n

[3]<\/a> Ambrosone CB, McCann SE, Freudenheim JL, Marshall JR, Zhang Y, Shields PG. Breast cancer risk in premenopausal women is inversely associated with consumption of broccoli, a source of isothiocyanates, but is not modified by GST genotype. J Nutr.<\/em> 2004 May;134(5):1134-8.
\nTomczyk J, Olejnik A. Sulforaphane–a possible agent in prevention and therapy of cancer. Postepy Hig Med Dosw<\/em> (Online). 2010 Nov 29;64:590-603.<\/p>\n

[4]<\/a> Taioli E, Garbers S, Bradlow HL, et al. Effects of indole-3-carbinol on the metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in smokers. Cancer Epidemiol Biomarkers Prev. 1997 Jul;6(7):517-22.<\/p>\n

[5]<\/a> Devanaboyina U. Effects of indole-3-carbinol (I3C) and phenethyl isothiocyanate (PEITC) on 7,12-dimethylbenz[a]anthracene (DMBA)-induced DNA adducts in rat mammary glands and liver (meeting abstract). Proc Annu Meet Am Assoc Cancer Res.1997(38):2427.
\nFriesen H, et al. Indole-3-carbinol as a chemopreventive agent in 2-amino-1- methyl-6- phenylimidazo[4,5-b]pyridine (PhIP) carcinogenesis: inhibition of PhIP-DNA adduct formation, acceleration of PhIP metabolism, and induction of cytochrome P450 in female F344 rats. Food Chem Toxicol (2000 Jan) 38(1):15-23.
\nJo EH, Kim SH, Ahn NS, et al. Efficacy of sulforaphane is mediated by p38 MAP kinase and caspase-7 activations in ER-positive and COX-2-expressed human breast cancer cells. Eur J Cancer Prev. <\/em>2007 Dec;16(6):505-10.<\/p>\n","protected":false},"excerpt":{"rendered":"

Broccoli, blomk\u00e5l og andre korsblomstrede gr\u00f8nsager indeholder helt unikke sundhedsfremmende plantestoffer, som har vist sig at hj\u00e6lpe med at forebygge starten p\u00e5 og standse progressionen af de fleste kr\u00e6ftformer, herunder brystkr\u00e6ft.[1] Broccoli kan standse cellecyklus f\u00f8r cellerne udvikler sig til … L\u00e6s resten →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":59,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-143","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/xn--nrdiagnosenerbrystkrft-o5b7b.dk\/index.php\/wp-json\/wp\/v2\/pages\/143","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/xn--nrdiagnosenerbrystkrft-o5b7b.dk\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/xn--nrdiagnosenerbrystkrft-o5b7b.dk\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/xn--nrdiagnosenerbrystkrft-o5b7b.dk\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/xn--nrdiagnosenerbrystkrft-o5b7b.dk\/index.php\/wp-json\/wp\/v2\/comments?post=143"}],"version-history":[{"count":1,"href":"https:\/\/xn--nrdiagnosenerbrystkrft-o5b7b.dk\/index.php\/wp-json\/wp\/v2\/pages\/143\/revisions"}],"predecessor-version":[{"id":145,"href":"https:\/\/xn--nrdiagnosenerbrystkrft-o5b7b.dk\/index.php\/wp-json\/wp\/v2\/pages\/143\/revisions\/145"}],"up":[{"embeddable":true,"href":"https:\/\/xn--nrdiagnosenerbrystkrft-o5b7b.dk\/index.php\/wp-json\/wp\/v2\/pages\/59"}],"wp:attachment":[{"href":"https:\/\/xn--nrdiagnosenerbrystkrft-o5b7b.dk\/index.php\/wp-json\/wp\/v2\/media?parent=143"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}